Toward the Molecular Flashlight: Preparation, Properties, and Photophysics of a Hypericin–luciferin Tethered Molecule¶

Jin Wen; Pramit Chowdhury; Nick J. Wills; Yvonne Wannemuehler; Jaehun Park; Sarathy Kesavan; S. Carpenter; G. A. Kraus; J. W. Petrich

doi:10.1562/0031-8655(2002)076<0153:TTMFPP>2.0.CO;2

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1 August 2002 Toward the Molecular Flashlight: Preparation, Properties, and Photophysics of a Hypericin–luciferin Tethered Molecule

Jin Wen, Pramit Chowdhury, Nick J. Wills, Yvonne Wannemuehler, Jaehun Park, Sarathy Kesavan, S. Carpenter, G. A. Kraus, J. W. Petrich

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Photochemistry and Photobiology, 76(2):153-157 (2002). https://doi.org/10.1562/0031-8655(2002)076<0153:TTMFPP>2.0.CO;2

Abstract

The synthesis of a molecule containing hypericin and luciferin moieties joined by a tether is reported. The light-induced (in vitro) antiviral activity as well as the photophysical properties of this new compound are measured and compared with those of the parent compounds, hypericin and pseudohypericin. This tethered molecule exhibits excited-state behavior that is very similar to that of its parent compounds and antiviral activity that is identical, within experimental error, to that of its more closely related parent compound, pseudohypericin. The implications for a photodynamic therapy that is independent of external light sources are discussed.

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Jin Wen, Pramit Chowdhury, Nick J. Wills, Yvonne Wannemuehler, Jaehun Park, Sarathy Kesavan, S. Carpenter, G. A. Kraus, and J. W. Petrich "Toward the Molecular Flashlight: Preparation, Properties, and Photophysics of a Hypericin–luciferin Tethered Molecule," Photochemistry and Photobiology 76(2), 153-157, (1 August 2002). https://doi.org/10.1562/0031-8655(2002)076<0153:TTMFPP>2.0.CO;2

Received: 10 December 2001; Accepted: 1 April 2002; Published: 1 August 2002

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